<p style="margin-right: 0cm; margin-left: 18pt; font-size: medium; font-family: &quot;Times New Roman&quot;, serif; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><strong><span style="font-family: Calibri, sans-serif;">Alcohol dependence or problematic alcohol use</span></strong><span style="font-family: Calibri, sans-serif;"><br data-start="263" data-end="266"><em data-start="268" data-end="361">This can affect how medicines work and may increase the risk of side effects or unsafe use.</em><o:p></o:p></span></p><p style="margin-right: 0cm; margin-left: 18pt; font-size: medium; font-family: &quot;Times New Roman&quot;, serif; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><strong><span style="font-family: Calibri, sans-serif;">Autoimmune conditions</span></strong><span class="apple-converted-space"><span style="font-family: Calibri, sans-serif;">&nbsp;</span></span><span style="font-family: Calibri, sans-serif;">(such as rheumatoid arthritis or Graves’ disease)<br data-start="440" data-end="443"><em data-start="445" data-end="539">Some medicines may not be suitable or may require extra monitoring in autoimmune conditions.</em><o:p></o:p></span></p><p style="margin-right: 0cm; margin-left: 18pt; font-size: medium; font-family: &quot;Times New Roman&quot;, serif; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><strong><span style="font-family: Calibri, sans-serif;">Depression requiring treatment with medication</span></strong><span style="font-family: Calibri, sans-serif;"><br data-start="593" data-end="596"><em data-start="598" data-end="677">Certain treatments can affect mood or interact with antidepressant medicines.</em><o:p></o:p></span></p><p style="margin-right: 0cm; margin-left: 18pt; font-size: medium; font-family: &quot;Times New Roman&quot;, serif; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><strong><span style="font-family: Calibri, sans-serif;">Epilepsy or a history of seizures</span></strong><span style="font-family: Calibri, sans-serif;"><br data-start="718" data-end="721"><em data-start="723" data-end="806">Some medicines can lower the seizure threshold or interfere with seizure control.</em><o:p></o:p></span></p><p style="margin-right: 0cm; margin-left: 18pt; font-size: medium; font-family: &quot;Times New Roman&quot;, serif; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><strong><span style="font-family: Calibri, sans-serif;">Galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption</span></strong><span style="font-family: Calibri, sans-serif;"><br data-start="896" data-end="899"><em data-start="901" data-end="996">Some medicines contain lactose or related sugars and may not be suitable in these conditions.</em><o:p></o:p></span></p><p style="margin-right: 0cm; margin-left: 18pt; font-size: medium; font-family: &quot;Times New Roman&quot;, serif; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><strong><span style="font-family: Calibri, sans-serif;">Heart disease or other significant heart conditions</span></strong><span style="font-family: Calibri, sans-serif;"><br data-start="1055" data-end="1058"><em data-start="1060" data-end="1130">Certain treatments can affect heart rate, rhythm, or blood pressure.</em><o:p></o:p></span></p><p style="margin-right: 0cm; margin-left: 18pt; font-size: medium; font-family: &quot;Times New Roman&quot;, serif; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><strong><span style="font-family: Calibri, sans-serif;">Kidney disease or reduced kidney function</span></strong><span style="font-family: Calibri, sans-serif;"><br data-start="1179" data-end="1182"><em data-start="1184" data-end="1262">Impaired kidney function can affect how medicines are cleared from the body.</em><o:p></o:p></span></p><p style="margin-right: 0cm; margin-left: 18pt; font-size: medium; font-family: &quot;Times New Roman&quot;, serif; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><strong><span style="font-family: Calibri, sans-serif;">Liver disease or ongoing liver problems</span></strong><span style="font-family: Calibri, sans-serif;"><br data-start="1309" data-end="1312"><em data-start="1314" data-end="1417">The liver plays a key role in processing medicines, and liver problems may increase the risk of harm.</em><o:p></o:p></span></p><p style="margin-right: 0cm; margin-left: 18pt; font-size: medium; font-family: &quot;Times New Roman&quot;, serif; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><strong><span style="font-family: Calibri, sans-serif;">Schizophrenia or bipolar disorder</span></strong><span style="font-family: Calibri, sans-serif;"><br data-start="1458" data-end="1461"><em data-start="1463" data-end="1540">Some treatments may worsen symptoms or interact with psychiatric medicines.</em><o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm; font-size: medium; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><o:p>&nbsp;</o:p></p>