irregular vaginal bleeding of unknown cause
diabetes
depression
epilepsy, migraine, asthma, kidney or heart problems
myocardial infarction (heart attack)
High blood pressure
Angina
Any liver disease or disturbance of liver function
jaundice or herpes during pregnancy
severe itching
Dubin-Johnson Syndrome (chronic jaundice (yellowing of the skin or eyes)) or Rotor Syndrome (jaundice in childhood)
an inherited disorder of the red blood pigment haemoglobin (porphyria)
cancer of the breast or genital tract
any serious medical condition which may require immediate hospitalisation