<p style="margin-right: 0cm; margin-left: 18pt; font-size: medium; font-family: &quot;Times New Roman&quot;, serif; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><strong><span style="font-family: Calibri, sans-serif;">Alcohol and sedating medicines</span></strong><span style="font-family: Calibri, sans-serif;"><br data-start="376" data-end="379"><em data-start="381" data-end="452">(Can increase drowsiness, slowed reactions, and excessive sleepiness)</em><br data-start="452" data-end="455">Alcohol; opioid painkillers; antihistamines; antipsychotic medicines; tricyclic antidepressants; mirtazapine; phenobarbital; primidone; muscle relaxants such as baclofen or tizanidine.<o:p></o:p></span></p><p style="margin-right: 0cm; margin-left: 18pt; font-size: medium; font-family: &quot;Times New Roman&quot;, serif; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><strong><span style="font-family: Calibri, sans-serif;">Blood pressure–lowering medicines</span></strong><span style="font-family: Calibri, sans-serif;"><br data-start="682" data-end="685"><em data-start="687" data-end="756">(May increase the risk of dizziness, light-headedness, or fainting)</em><br data-start="756" data-end="759">Alpha-blockers (e.g. doxazosin, alfuzosin, tamsulosin, prazosin); beta-blockers; calcium-channel blockers; diuretics (water tablets); nitrates; vasodilators such as hydralazine, minoxidil, or sodium nitroprusside.<o:p></o:p></span></p><p style="margin-right: 0cm; margin-left: 18pt; font-size: medium; font-family: &quot;Times New Roman&quot;, serif; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><strong><span style="font-family: Calibri, sans-serif;">Centrally acting blood pressure medicines</span></strong><span style="font-family: Calibri, sans-serif;"><br data-start="1023" data-end="1026"><em data-start="1028" data-end="1096">(Act on the brain and may increase sedation or low blood pressure)</em><br data-start="1096" data-end="1099">Clonidine; guanfacine; lofexidine; methyldopa; moxonidine; diazoxide.<o:p></o:p></span></p><p style="margin-right: 0cm; margin-left: 18pt; font-size: medium; font-family: &quot;Times New Roman&quot;, serif; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><strong><span style="font-family: Calibri, sans-serif;">Medicines affecting melatonin levels or blood cells</span></strong><span style="font-family: Calibri, sans-serif;"><br data-start="1229" data-end="1232"><em data-start="1234" data-end="1299">(May increase side effects or alter how melatonin is processed)</em><br data-start="1299" data-end="1302">Ritonavir; myelosuppressive medicines.<o:p></o:p></span></p>